The results of action flow according to the law of creature. Is karma supreme ? it is insentient.
The creator remaining everywhere makes each one to play his role in life according their karma.. that which is not destined will not happen despite every effort .what is destined is bound to happen. This is certain. therefore the best course is to remain silent.
All the activities which the body is to go through are determined when it first comes into existence. It does not rest with you to accept or reject them. The only freedom you have is to turn your mind inward and renounce activities there: Maharishi Ramana.